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Advances in intravesical drug delivery systems to treat bladder cancer

Kolawole, O. M., Lau, W. M., Mostafid, H. and Khutoryanskiy, V. (2017) Advances in intravesical drug delivery systems to treat bladder cancer. International Journal of Pharmaceutics, 532 (1). pp. 105-117. ISSN 0378-5173

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To link to this item DOI: 10.1016/j.ijpharm.2017.08.120

Abstract/Summary

Chemotherapeutic agents administered intravesically to treat bladder cancer have limited efficacy due to periodic dilution and wash-out during urine formation and elimination. This review describes the pathophysiology, prevalence and staging of bladder cancer, and discusses several formulation strategies used to improve drug residence within the bladder. These include the use of amphiphilic copolymers, mucoadhesive formulations, hydrogels, floating systems, and liposomes. Various in vitro and in vivo models recently employed for intravesical drug delivery studies are discussed. Some of the challenges that have prevented the clinical use of some promising formulations are identified.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmacy Practice Research Group
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:73165
Publisher:Elsevier

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