Accessibility navigation


Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities

Hartweg, M., Edwards-Gayle, C. J. C., Radvar, E., Collis, D., Reza, M., Kaupp, M., Steinkoenig, J., Ruokolainen, J., Rambo, R., Barner-Kowollik, C., Hamley, I. W., Azevedo, H. S. and Becer, C. R. (2018) Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities. Polymer Chemistry, 9 (4). pp. 482-489. ISSN 1759-9954

[img]
Preview
Text - Accepted Version
· Please see our End User Agreement before downloading.

834kB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1039/c7py01953j

Abstract/Summary

Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide–peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide–peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:75166
Uncontrolled Keywords:Organic Chemistry, Biochemistry, Bioengineering, Polymers and Plastics
Publisher:Royal Society of Chemistry

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation