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Formulation of carbopol®/Poly(2-ethyl-2-oxazoline)s mucoadhesive tablets for buccal delivery of hydrocortisone

Ruiz-Rubio, L., Alonso, M. L., Pérez-Álvarez, L., Alonso, R. M., Vilas, J. L. and Khutoryanskiy, V. (2018) Formulation of carbopol®/Poly(2-ethyl-2-oxazoline)s mucoadhesive tablets for buccal delivery of hydrocortisone. Polymers, 10 (2). 175. ISSN 2073-4360

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To link to this item DOI: 10.3390/polym10020175

Abstract/Summary

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:75575
Publisher:MDPI

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