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Progress and current trends in the synthesis of novel polymers with enhanced mucoadhesive properties

Brannigan, R. P. and Khutoryanskiy, V. V. (2019) Progress and current trends in the synthesis of novel polymers with enhanced mucoadhesive properties. Macromolecular Bioscience, 19 (10). e1900194. ISSN 1616-5187

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To link to this item DOI: 10.1002/mabi.201900194

Abstract/Summary

Mucoadhesion is defined as the adherence of a synthetic or natural polymer to a mucosal membrane via physical or chemical interactions. Mucoadhesive materials are widely used to develop dosage forms for transmucosal drug delivery via ocular, nasal, esophageal, oral, vaginal, rectal, and intravesical routes of administration. This review will discuss some of the most prominent and recent synthetic methodologies employed to modify polymeric materials in order to enhance their mucoadhesive properties. This includes chemical conjugation of polymers with molecules bearing thiol‐, catechol‐, boronate‐, acrylate‐, methacrylate‐, maleimide‐, and N‐hydroxy(sulfo)succinimide ester‐ groups.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:85336
Publisher:Wiley

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