Accessibility navigation


An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow

France, J., Hanigan, M. D., Reynolds, C. K., Dijkstra, J., Crompton, L. A., Maas, J. A., Bequette, B. J., Metcalf, J. A., Lobley, G. E., MacRae, J. C. and Beever, D. E. (1999) An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow. Journal of Theoretical Biology, 198 (1). pp. 121-133. ISSN 0022-5193

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1006/jtbi.1999.0897

Abstract/Summary

An isotope dilution model for partitioning leucine uptake by the liver of the lactating dairy cow is constructed and solved in the steady state[ If assumptions are made, model solution permits calculation of the rate of leucine uptake from portal and hepatic arterial blood supply,leucine export into the hepatic vein, leucine oxidation and transamination, and synthesis and degradation of hepatic constitutive and export proteins[ The model requires the measurement of plasma flow rate through the liver in combination with leucine concentrations and plateau isotopic enrichments in arterial, portal and hepatic plasma during a constant infusion of [l-13C]leucine tracer. The model can be applied to other amino acids with similar metabolic fates and will provide a means for assessing the impact of hepatic metabolism on amino acid availability to peripheral tissues[ This is of particular importance when considering the dairy cow and the requirements of the mammary gland for milk protein synthesis.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Agriculture, Policy and Development > Food Production and Quality Division > Animal, Dairy and Food Chain Sciences (ADFCS)
ID Code:90828
Publisher:Elsevier

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation