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Items where Author is "Lewis, Dr Patrick"

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Hartlova, A., Herbst, S., Peltier, J., Rodgers, A., Bilkei-Gorzo, O., Fearns, A., Dill, B. D., Lee, H., Rowan, F., Cowley, S. A., Davies, P., Lewis, P. A., Ganley, I. G., Martinez, J., Alessi, D. R., Reith, A. D., Trost, M. and Gutierrez, M. G. (2018) LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. The EMBO Journal, 37 (12). e98694. ISSN 0261-4189 doi: https://doi.org/10.15252/embj.201798694

Ferrari, R., Kia, D., Tomkins, J., Hardy, J., Wood, N., Lovering, R., Lewis, P. and Manzoni, C. (2018) Stratification of candidate genes for Parkinson’s disease using weighted protein interaction network analysis. BMC Genomics, 19. 452. ISSN 1471-2164 doi: https://doi.org/10.1186/s12864-018-4804-9

Tomkins, J. E., Dihanich, S., Beilina, A., Ferrari, R., Ilacqua, N., Cookson, M. R., Lewis, P. A. and Manzoni, C. (2018) Comparative protein interaction network analysis identifies shared and distinct functions for the human ROCO proteins. Proteomics. ISSN 1615-9853 doi: https://doi.org/10.1002/pmic.201700444

Manzoni, C., Mamais, A., Dihanich, S., Soutar, M. P. M., Plun-Favreau, H., Bandopadhyay, R., Abeti, R., Giunti, P., Hardy, J., Cookson, M. R., Tooze, S. A. and Lewis, P. A. (2018) mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition. Bioscience Reports, 38 (2). BSR20171669. ISSN 0144-8463 doi: https://doi.org/10.1042/BSR20171669

Manzoni, C., Kia, D. A., Vandrovcova, J., Hardy, J., Wood, N. W., Lewis, P. A. and Ferrari, R. (2018) Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences. Briefings In Bioinformatics, 19 (2). pp. 286-302. ISSN 1467-5463 doi: https://doi.org/10.1093/bib/bbw114

Price, A., Manzoni, C., Cookson, M. R. and Lewis, P. A. (2018) The LRRK2 signalling system. Cell and Tissue Research. ISSN 0302-766X doi: https://doi.org/10.1007/s00441-017-2759-9

Civiero, L., Cogo, S., Kiekens, A., Morganti, C., Tessari, I., Lobbestael, E., Baekelandt, V., Taymans, J.-M., Chartier-Harlin, M.-C., Franchin, C., Arrigoni, G., Lewis, P. A., Piccoli, G., Bubacco, L., Cookson, M. R., Pinton, P. and Greggio, E. (2017) PAK6 phosphorylates 14-3-3γ to regulate steady state phosphorylation of LRRK2. Frontiers in Molecular Neuroscience, 10. 417. ISSN 1662-5099 doi: https://doi.org/10.3389/fnmol.2017.00417

Murthy, M. N., Blauwendraat, C., Guelfi, S., Hardy, J., Lewis, P. A. and Trabzuni, D. (2017) Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3. Neurogenetics, 18 (3). pp. 121-133. ISSN 1364-6745 doi: https://doi.org/10.1007/s10048-017-0514-8

Noyce, A. J., Kia, D. A., Hemani, G., Nicolas, A., Price, T. R., De Pablo-Fernandez, E., Haycock, P. C., Lewis, P. A., Foltynie, T., Davey Smith, G., Schrag, A., Lees, A. J., Hardy, J., Singleton, A., Nalls, M. A., Pearce, N., Lawlor, D. A. and Wood, N. W. (2017) Estimating the causal influence of body mass index on risk of Parkinson disease: a Mendelian randomisation study. PLoS Medicine, 14 (6). e1002314. ISSN 1549-1676 doi: https://doi.org/10.1371/journal.pmed.1002314

Ferrari, R., Lovering, R. C., Hardy, J., Lewis, P. A. and Manzoni, C. (2017) Weighted protein interaction network analysis of frontotemporal dementia. Journal of Proteome Research, 16 (2). pp. 999-1013. ISSN 1535-3907 doi: https://doi.org/10.1021/acs.jproteome.6b00934

Lubbe, S. J., Escott-Price, V., Gibbs, J. R., Nalls, M. A., Bras, J., Price, T. R., Nicolas, A., Jansen, I. E., Mok, K. Y., Pittman, A. M., Tomkins, J. E., Lewis, P. A., Noyce, A. J., Lesage, S., Sharma, M., Schiff, E. R., Levine, A. P., Brice, A., Gasser, T., Hardy, J., Heutink, P., Wood, N. W., Singleton, A. B., Williams, N. M. and Morris, H. R. (2016) Additional rare variant analysis in Parkinson's Disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. Human Molecular Genetics, 25 (24). pp. 5483-5489. ISSN 1460-2083 doi: https://doi.org/10.1093/hmg/ddw348

Kara, E., Tucci, A., Manzoni, C., Lynch, D. S., Elpidorou, M., Bettencourt, C., Chelban, V., Manole, A., Hamed, S., Haridy, N., Federoff, M., Preza, E., Hughes, D., Pittman, A., Jaunmuktane, Z., Brandner, S., Xiromerisiou, G., Wiethoff, S., Schottlaender, L., Proukakis, C., Morris, H., Warner, T., Bhatia, K., Korlipara, P., Singleton, A., Hardy, J., Wood, N., Lewis, P. and Houlden, H. (2016) Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain : A Journal of Neurology, 139 (7). pp. 1904-1918. ISSN 1460-2156 doi: https://doi.org/10.1093/brain/aww111

Lewis, P. (2016) Measuring lactase enzymatic activity in the teaching lab. Journal of Visualized Experiments. ISSN 1940-087X (In Press)

Civiero, L., Cirnaru, M. D., Beilina, A., Rodella, U., Russo, I., Belluzzi, E., Lobbestael, E., Reyniers, L., Hondhamuni, G., Lewis, P. A., Van den Haute, C., Baekelandt, V., Bandopadhyay, R., Bubacco, L., Piccoli, G., Cookson, M. R., Taymans, J.-M. and Greggio, E. (2015) Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. Journal of Neurochemistry, 135 (6). pp. 1242-1256. ISSN 0022-3042 doi: https://doi.org/10.1111/jnc.13369

Kiely, A., Ling, H., Asi, Y., Kara, E., Proukakis, C., Schapira, A., Morris, H., Roberts, H., Lubbe, S., Limousin, P., Lewis, P., Lees, A., Quinn, N., Hardy, J., Love, S., Revesz, T., Houlden, H. and Holton, J. (2015) Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular Neurodegeneration, 10 (1). 41. ISSN 1750-1326 doi: https://doi.org/10.1186/s13024-015-0038-3

Manzoni, C., Denny, P., Lovering, R. C. and Lewis, P. A. (2015) Computational analysis of the LRRK2 interactome. PeerJ, 3. 778. ISSN 2167-8359 doi: https://doi.org/10.7717/peerj.778

Tsika, E., Glauser, L., Moser, R., Fiser, A., Daniel, G., Sheerin, U.-M., Lees, A., Troncoso, J. C., Lewis, P. A., Bandopadhyay, R., Schneider, B. L. and Moore, D. J. (2014) Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Human Molecular Genetics, 23 (17). pp. 4621-4638. ISSN 1460-2083 doi: https://doi.org/10.1093/hmg/ddu178

Mamais, A., Chia, R., Beilina, A., Hauser, D. N., Hall, C., Lewis, P. A., Cookson, M. R. and Bandopadhyay, R. (2014) Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. Journal of biological chemistry, 289 (31). pp. 21386-21400. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M113.528463

Civiero, L., Dihanich, S., Lewis, P. A. and Greggio, E. (2014) Genetic, structural, and molecular insights into the function of ras of complex proteins domains. Chemistry and Biology, 21 (7). pp. 809-818. ISSN 1074-5521 doi: https://doi.org/10.1016/j.chembiol.2014.05.010

Dihanich, S., Civiero, L., Manzoni, C., Mamais, A., Bandopadhyay, R., Greggio, E. and Lewis, P. A. (2014) GTP binding controls complex formation by the human ROCO protein MASL1. FEBS Journal, 281 (1). pp. 261-274. ISSN 1742-464X doi: https://doi.org/10.1111/febs.12593

Schulte, E. C., Ellwanger, D. C., Dihanich, S., Manzoni, C., Stangl, K., Schormair, B., Graf, E., Eck, S., Mollenhauer, B., Haubenberger, D., Pirker, W., Zimprich, A., Brücke, T., Lichtner, P., Peters, A., Gieger, C., Trenkwalder, C., Mewes, H.-W., Meitinger, T., Lewis, P. A., Klünemann, H. H. and Winkelmann, J. (2014) Rare variants in LRRK1 and Parkinson's disease. Neurogenetics, 15 (1). pp. 49-57. ISSN 1364-6745 doi: https://doi.org/10.1007/s10048-013-0383-8

Manzoni, C., Mamais, A., Dihanich, S., McGoldrick, P., Devine, M. J., Zerle, J., Kara, E., Taanman, J.-W., Healy, D. G., Marti-Masso, J.-F., Schapira, A. H., Plun-Favreau, H., Tooze, S., Hardy, J., Bandopadhyay, R. and Lewis, P. A. (2013) Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochemical and Biophysical Research Communications, 441 (4). pp. 862-866. ISSN 0006-291X doi: https://doi.org/10.1016/j.bbrc.2013.10.159

Manzoni, C., Mamais, A., Dihanich, S., Abeti, R., Soutar, M. P. M., Plun-Favreau, H., Giunti, P., Tooze, S. A., Bandopadhyay, R. and Lewis, P. A. (2013) Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochimica Et Biophysica Acta-Molecular Cell Research, 1833 (12). pp. 2900-2910. ISSN 0167-4889 doi: https://doi.org/10.1016/j.bbamcr.2013.07.020

Jebelli, J. D., Dihanich, S., Civiero, L., Manzoni, C., Greggio, E. and Lewis, P. A. (2012) GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. Scientific Reports, 2. 695. ISSN 2045-2322 doi: https://doi.org/10.1038/srep00695

Patani, R., Lewis, P. A., Trabzuni, D., Puddifoot, C. A., Wyllie, D. J. A., Walker, R., Smith, C., Hardingham, G. E., Weale, M., Hardy, J., Chandran, S. and Ryten, M. (2012) Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry, 122 (4). pp. 738-751. ISSN 0022-3042 doi: https://doi.org/10.1111/j.1471-4159.2012.07825.x

Lewis, P. A. and Cookson, M. R. (2012) Gene expression in the Parkinson's disease brain. Brain Research Bulletin, 88 (4). pp. 302-312. ISSN 0361-9230 doi: https://doi.org/10.1016/j.brainresbull.2011.11.016

Devine, M. J., Kaganovich, A., Ryten, M., Mamais, A., Trabzuni, D., Manzoni, C., McGoldrick, P., Chan, D., Dillman, A., Zerle, J., Horan, S., Taanman, J.-W., Hardy, J., Marti-Masso, J.-F., Healy, D., Schapira, A. H., Wolozin, B., Bandopadhyay, R., Cookson, M. R., van der Brug, M. P. and Lewis, P. A. (2011) Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue. PLoS ONE, 6 (7). e22489. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0022489

Li, Y., Dunn, L., Greggio, E., Krumm, B., Jackson, G. S., Cookson, M. R., Lewis, P. A. and Deng, J. (2009) The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1792 (12). pp. 1194-1197. ISSN 0925-4439 doi: https://doi.org/10.1016/j.bbadis.2009.09.010

Deng, J., Lewis, P. A., Greggio, E., Sluch, E., Beilina, A. and Cookson, M. A. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proceedings of the National Academy of Sciences, 105 (5). pp. 1499-1504. ISSN 1091-6490 doi: https://doi.org/10.1073/pnas.0709098105

Book or Report Section

Manzoni, C. and Lewis, P. A. (2017) LRRK2 and autophagy. In: Rideout, H. J. (ed.) Leucine-Rich Repeat Kinase 2 (LRRK2). Advances in Neurobiology (ISSN:2190-5215), 14. Springer International Publishing, Cham, Switzerland, pp. 89-105. ISBN 9783319499673 doi: https://doi.org/10.1007/978-3-319-49969-7_5

This list was generated on Mon Aug 20 01:21:31 2018 UTC.

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