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Conformational control of bis-urea self-assembled supramolecular pH switchable low-molecular-weight hydrogelators

O'Donnell, A., Gavriel, A., Christie, W., Chippindale, A., German, I. and Hayes, W. ORCID: (2021) Conformational control of bis-urea self-assembled supramolecular pH switchable low-molecular-weight hydrogelators. ARKIVOC, 6. pp. 222-241. ISSN 1551-7004

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To link to this item DOI: 10.24820/ark.5550190.p011.581


We report the synthesis and investigation into the structure-property relationships of eight different low molecular weight hydrogelators based on a bisaromatic urea core unit, all of which form gels as the pH of the solution is lowered. The low molecular weight hydrogelators are functionalized with carboxylic acid moieties on one aromatic ring, and the other aromatic ring features a nitro functional group either in the meta- or para-position relative to the urea linkage. Ortho-methyl substituents were installed on the aromatic rings to enforce a non-coplanar arrangement between the phenyl and urea moieties. Gel formation was triggered by the addition of a mineral acid or the ring-opening hydrolysis of glucono-δ-lactone. The low molecular weight hydrogelators were studied by a variety of analytical techniques, including NMR spectroscopy and rheology. In addition, their ability to uptake a dye, methylene blue, was determined by UV-vis spectroscopy.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:100482
Publisher:Arkat USA Inc


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