A 25-year review of sequential methodology in clinical studiesTodd, S. ORCID: https://orcid.org/0000-0002-9981-923X (2007) A 25-year review of sequential methodology in clinical studies. Stat Med, 26 (2). pp. 237-52. ISSN 0277-6715 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1002/sim.2763 Abstract/SummaryThis paper explores the theoretical developments and subsequent uptake of sequential methodology in clinical studies in the 25 years since Statistics in Medicine was launched. The review examines the contributions which have been made to all four phases into which clinical trials are traditionally classified and highlights major statistical advancements, together with assessing application of the techniques. The vast majority of work has been in the setting of phase III clinical trials and so emphasis will be placed here. Finally, comments are given indicating how the subject area may develop in the future.
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