Accessibility navigation

Diversity in genetic regulation of bacterial fimbriae assembled by the Chaperone Usher pathway

Gahlot, D. K. ORCID:, Taheri, N. ORCID: and MacIntyre, S. (2023) Diversity in genetic regulation of bacterial fimbriae assembled by the Chaperone Usher pathway. International Journal of Molecular Sciences, 24 (1). 161. ISSN 1422-0067

Text (Open access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.


It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.3390/ijms24010161


Bacteria express different types of hair-like proteinaceous appendages on their cell surface known as pili or fimbriae. These filamentous structures are primarily involved in the adherence of bacteria to both abiotic and biotic surfaces for biofilm formation and/or virulence of non-pathogenic and pathogenic bacteria. In pathogenic bacteria, especially Gram-negative bacteria, fimbriae play a key role in bacteria–host interactions which are critical for bacterial invasion and infection. Fimbriae assembled by the Chaperone Usher pathway (CUP) are widespread within the Enterobacteriaceae, and their expression is tightly regulated by specific environmental stimuli. Genes essential for expression of CUP fimbriae are organised in small blocks/clusters, which are often located in proximity to other virulence genes on a pathogenicity island. Since these surface appendages play a crucial role in bacterial virulence, they have potential to be harnessed in vaccine development. This review covers the regulation of expression of CUP-assembled fimbriae in Gram-negative bacteria and uses selected examples to demonstrate both dedicated and global regulatory mechanisms.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:109601
Uncontrolled Keywords:Review, Gram-negative bacteria, Chaperone Usher Pathway (CUP) fimbriae, FGL & FGS class, expression regulation mechanisms, lifestyle & pathogenesis, vaccine development


Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation