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The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

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El Kaim, L., Gautier, L., Grimaud, L., Harwood, L.M. ORCID: https://orcid.org/0000-0002-8442-7380 and Michaut, V. (2003) The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions. Green Chemistry, 5 (4). pp. 477-479. ISSN 1463-9262 doi: 10.1039/b306242b

Abstract/Summary

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

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Item Type Article
URI https://centaur.reading.ac.uk/id/eprint/11243
Identification Number/DOI 10.1039/b306242b
Refereed Yes
Divisions Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
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