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Syntheses of ethyl 3-deoxy-3,3-difluoro-D-arabino-heptulosonate and analogues

Li, Y., Drew, M.G.B., Welchman, E.V., Shirvastava, R.K., Jiang, S.D., Valentine, R. and Singh, G. (2004) Syntheses of ethyl 3-deoxy-3,3-difluoro-D-arabino-heptulosonate and analogues. Tetrahedron, 60 (31). pp. 6523-6531. ISSN 0040-4020

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To link to this item DOI: 10.1016/j.tet.2004.06.048

Abstract/Summary

The difluormated analogues of 3-deoxy-D-arabino-heptulosonic acid (DAH) 12, 24 and its enantiomer have been synthesised from D- and L-crythrose via a Reformatsky reaction which gave a mixture of diastereoiosmers in favour of the anti isomer. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11429
Uncontrolled Keywords:Reformatsky reaction, shikimate pathway, carbohydrate, fluorinated ulosonatm, enzyme inhibitors , SHIKIMATE PATHWAY, APICOMPLEXAN PARASITES, ACID, SYNTHASE, NUCLEOSIDES, DERIVATIVES

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