Water-soluble tripeptide A beta(9-11) forms amyloid-like fibrils and exhibits neurotoxicityNaskar, J., Drew, M. G. B., Deb, I., Das, S. and Banerjee, A. (2008) Water-soluble tripeptide A beta(9-11) forms amyloid-like fibrils and exhibits neurotoxicity. Organic Letters, 10 (13). pp. 2625-2628. ISSN 1523-7060 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1021/ol8007217 Abstract/SummaryA water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides A,beta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.
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