A short water-soluble self-assembling peptide forms amyloid-like fibrilsRay, S., Das, A.K., Drew, M.G.B. and Banerjee, A. (2006) A short water-soluble self-assembling peptide forms amyloid-like fibrils. Chemical Communications (40). pp. 4230-4232. ISSN 1359-7345 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1039/b607657b Abstract/SummaryA water-soluble tripeptide Val-Ile-Ala (VIA) 1, bearing sequence identity with the C-terminal portion of the Alzheimer A beta-peptide (A beta(40-42)), self-assembles, in crystalline form, to produce an intermolecularly hydrogen bonded supramolecular beta-sheet structure which self-associates to form straight, unbranched nanofibrils exhibiting amyloid-like behavior; in contrast, the synthetic tripeptide Ala-Val-Ile (AVI) 2 self-assembles to produce a beta-sheet structure that forms branched nanofibrils which do not show any characteristic features of amyloid-like fibrils.
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