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Enantioselective detection of L-serine

Stanley, S., Percival, C.J., Morel, T., Braithwaite, A., Newton, M.I., McHale, G. and Hayes, W. (2003) Enantioselective detection of L-serine. Sensors and Actuators B - Chemical, 89 (1-2). pp. 103-106. ISSN 0925-4005

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An acoustic wave sensor coated with an artificial biomimetic recognition element has been developed to selectively detect the amino acid L-serine. A highly specific non-covalently imprinted polymer was cast on one electrode of a quartz crystal microbalance (QCM) as a thin permeable film. Selective rebinding of the L-serine was observed as a frequency shift in the QCM with a detection limit of 2 ppb and for concentrations up to 0.4 ppm. The sensor binding is shown to be capable of discrimination between L- and D-stereoisomers of serine as a result of the enantioselectivity of the imprinted binding sites. (C) 2002 Elsevier Science B.V. All rights reserved.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11636
Uncontrolled Keywords:L-serine, molecular imprinted polymers (MIPs), enantioselectivity, quartz crystal microbalance (QCM), acoustic wave , MOLECULARLY IMPRINTED POLYMERS, QUARTZ-CRYSTAL MICROBALANCE, RECOGNITION, SENSOR, CHEMISTRY, MONOMERS, TEMPLATE, BINDING

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