Aziridine synthesis via nucleophilic attack of carbene equivalents on imines: the aza-Darzens reactionSweeney, J.B. (2009) Aziridine synthesis via nucleophilic attack of carbene equivalents on imines: the aza-Darzens reaction. European Journal of Organic Chemistry (29). pp. 4911-4919. ISSN 1434-193X Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1002/ejoc.200900211 Abstract/SummaryThe development of new methods for the efficient synthesis of aziridines has been of considerable interest to researchers for more than 60 years, but no single method has yet emerged as uniformly applicable, especially for asymmetric synthesis of chiral aziridines. One method which has been intensely examined and expanded of late involves the nucleophilic addition to imines by anions bearing a-leaving groups; by analogy with the glycidate epoxide synthesis, these processes are often described as "aza-Darzens reactions". This Microreview gives a summary of the area, with a focus on contemporary developments. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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