Efficient proton transport modelling for proton beam therapy and biological quantification

Ashby, B. S., Chronholm, V., Hajnal, D. K., Lukyanov, A., MacKenzie, K., Pim, A. and Pryer, T. (2025) Efficient proton transport modelling for proton beam therapy and biological quantification. Journal of Mathematical Biology, 90. 47. ISSN 1432-1416 doi: 10.1007/s00285-025-02212-1

Abstract/Summary

In this work, we present a fundamental mathematical model for proton transport, tailored to capture the key physical processes underpinning Proton Beam Therapy (PBT). The model provides a robust and computationally efficient framework for exploring various aspects of PBT, including dose delivery, linear energy transfer, treatment planning and the evaluation of relative biological effectiveness. Our findings highlight the potential of this model as a complementary tool to more complex and computationally intensive simulation techniques currently used in clinical practice.

Item Type	Article
URI	https://centaur.reading.ac.uk/id/eprint/122427
Identification Number/DOI	10.1007/s00285-025-02212-1
Refereed	Yes
Divisions	Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics
Publisher	Springer
Download/View statistics	View download statistics for this item