Platelet ITIM-containing receptors
Soriano Jerez, E. M. and Hughes, C. E.
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1007/978-3-031-96340-7_19 Abstract/SummaryPlatelets express several immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors which regulate platelet production, platelet activation, adhesion, and thrombus stability, and influence both haemostatic and immune responses. In this chapter we detail the structure, expression, ligands and signalling pathways of this family of receptors, and cover their biological relevance in platelets and megakaryocytes. PECAM-1, G6b-B, and LAIR-1 (megakaryocyte-specific) modulate platelet activation. CEACAM-1/2 and LILRB2 balance platelet adhesion and immune interactions. TLT-1 enhances platelet aggregation post-activation, in addition to a role in cancer progression. The downstream signalling proteins, SHP-1 and SHP-2, are essential for the inhibitory signalling of these receptors, and their loss can lead to platelet hyperactivation, increasing thrombotic risk. In this chapter we also discuss strategies for therapeutic targeting and fine-tuning of platelet reactivity. Collectively, this family of receptors play distinct roles in platelet function and regulation, presenting novel opportunities for treatments.
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Platelet ITIM-containing receptors
Soriano Jerez, E. M. and Hughes, C. E.
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1007/978-3-031-96340-7_19 Abstract/SummaryPlatelets express several immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors which regulate platelet production, platelet activation, adhesion, and thrombus stability, and influence both haemostatic and immune responses. In this chapter we detail the structure, expression, ligands and signalling pathways of this family of receptors, and cover their biological relevance in platelets and megakaryocytes. PECAM-1, G6b-B, and LAIR-1 (megakaryocyte-specific) modulate platelet activation. CEACAM-1/2 and LILRB2 balance platelet adhesion and immune interactions. TLT-1 enhances platelet aggregation post-activation, in addition to a role in cancer progression. The downstream signalling proteins, SHP-1 and SHP-2, are essential for the inhibitory signalling of these receptors, and their loss can lead to platelet hyperactivation, increasing thrombotic risk. In this chapter we also discuss strategies for therapeutic targeting and fine-tuning of platelet reactivity. Collectively, this family of receptors play distinct roles in platelet function and regulation, presenting novel opportunities for treatments.
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