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Low-molecular weight organogel matrices as crystallisation media for active pharmaceutical ingredients

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Tareq, A., Hyder, M., Chippindale, A. M. ORCID: https://orcid.org/0000-0002-5918-8701, Spencer, N., Mohan, S. ORCID: https://orcid.org/0000-0001-5388-088X, Kaur, A., Hallett, J. ORCID: https://orcid.org/0000-0002-9747-9980, Zinn, T., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 and Hayes, W. ORCID: https://orcid.org/0000-0003-0047-2991 (2026) Low-molecular weight organogel matrices as crystallisation media for active pharmaceutical ingredients. Journal of Materials Chemistry B. ISSN 0959-9428 doi: 10.1039/D6TB00302H (In Press)

Abstract/Summary

The vast majority of small-molecule active pharmaceutical ingredients (APIs) are formulated in the crystalline state, for reasons including thermodynamic stability, ease of purification and characterisation, and better control over polymorphism. However, the selective crystallisation of polymorphic APIs provides a significant hurdle to overcome, especially in the case of API co-crystals. Herein we report a series of low-molecular-weight organogels (LMWGs) which can be used to selectively crystallise APIs. In solution, these LMWGs (2-10 mg mL-1) self-assemble through hydrogen bonding to form stable gels which feature nano-structured morphologies. When utilised as crystallisation media, these LMWGs can influence crystal growth, as evidenced by the discovery of two novel 1:1 co-crystals of chlorzoxazone with nicotinamide and chlorzoxazone with isonicotinamide. This work highlights the potential of LMWGs as another means of controlling API crystallisation.

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Item Type Article
URI https://centaur.reading.ac.uk/id/eprint/128951
Identification Number/DOI 10.1039/D6TB00302H
Refereed Yes
Divisions Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher Royal Society of Chemistry
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