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Interpolymer complexes of hydroxy-propylmethylcellulose with polycarboxylic acids in aqueous solutions

Mangazbaeva, R.A., Mun, G.A., Nurkeeva, Z.S. and Khutoryanskiy, V.V. (2006) Interpolymer complexes of hydroxy-propylmethylcellulose with polycarboxylic acids in aqueous solutions. Polymer International, 55 (6). pp. 668-674. ISSN 0959-8103

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To link to this item DOI: 10.1002/pi.2012


The interactions between hydroxypropylmethylcellulose (HPMC) and poly(acrylic acid) (PAA) as well as poly(methacrylic acid) (PMMA) resulting in formation of hydrophobic interpolymer complexes (IPC) via hydrogen bonding have been studied in aqueous solutions in acidic medium. The formation of IPC of two different compositions (2:1 and 4:1) has been detected for complexes of PAA and HPMC. The critical pH values for complexation of HPMC with PAA and PMAA were determined by the turbidimetric method. It was found that PAA shows the lower complexation ability compared to PMAA due to the more hydrophobic nature of the latter polyacid. The temperature-induced phase separation in HPMC-PAA solution mixtures depends greatly on the components ratio and PAA molecular weight. The complexation ability of hydroxypropylmethylcellulose with respect to poly(acrylic acid) was found to be similar to the complexation ability of methylcellulose, lower than that of hydroxypropylcellulose and higher than that of hydroxyethylcellulose. (c) 2006 Society of Chemical Industry.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13692
Uncontrolled Keywords:interpolymer complexes, hydrogen bonding, cellulose ethers, lower, critical solution temperature, phase separation, POLY(ACRYLIC ACID), CONTROLLED-RELEASE, MALEIC-ACID, BEHAVIOR, HYDROXYPROPYLCELLULOSE, COPOLYMERS, TABLETS, SYSTEMS

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