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Asymmetric synthesis using catalysts containing multiple stereogenic centres and a trans-1,2-diaminocyclohexane core; reversal of predominant enantioselectivity upon N-alkylation

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Cobb, A.J.A. and Marson, C.M. (2005) Asymmetric synthesis using catalysts containing multiple stereogenic centres and a trans-1,2-diaminocyclohexane core; reversal of predominant enantioselectivity upon N-alkylation. Tetrahedron, 61 (5). pp. 1269-1279. ISSN 0040-4020

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To link to this item DOI: 10.1016/j.tet.2004.11.030

Abstract/Summary

N-Methylation of ligands containing a trans-1,2-diaminocyclohexane core and multiple stereogenic centres is shown to provide the product of the opposite configuration in significant enantiomeric excess, in the addition of diethylzinc to aldehydes. Some of the ligands were effective in an asymmetric Michael addition. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13777
Uncontrolled Keywords:amine ligands, catalysis, asymmetric synthesis, carbonyl alkylation, Michael addition , ORGANOZINC REAGENTS, CARBONYL-COMPOUNDS, AMINO-ALCOHOLS, MOLECULAR RECOGNITION, TETRADENTATE LIGANDS, ALDEHYDES, DIETHYLZINC, COMPLEXES, DIALKYLZINCS, DERIVATIVES
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