Accessibility navigation

Neural response to emotional prosody in schizophrenia and in bipolar affective disorder

Mitchell, R. L. C., Elliott, R., Barry, M., Cruttenden, A. and Woodruff, P. W. R. (2004) Neural response to emotional prosody in schizophrenia and in bipolar affective disorder. British Journal of Psychiatry, 184 (3). pp. 223-230. ISSN 0007-1250

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Official URL:


Background Evidence suggests a reversal of the normal left-lateralised response to speech in schizophrenia. Aims To test the brain's response to emotional prosody in schizophrenia and bipolar disorder. Method BOLD contrast functional magnetic resonance imaging of subjects while they passively listened or attended to sentences that differed in emotional prosody Results Patients with schizophrenia exhibited normal right-lateralisation of the passive response to 'pure' emotional prosody and relative left-lateralisation of the response to unfiltered emotional prosody When attending to emotional prosody, patients with schizophrenia activated the left insula more than healthy controls. When listening passively, patients with bipolar disorder demonstrated less activation of the bilateral superior temporal gyri in response to pure emotional prosody, and greater activation of the left superior temporal gyrus in response to unfiltered emotional prosody In both passive experiments, the patient groups activated different lateral temporal lobe regions. Conclusions Patients with schizophrenia and bipolar disorder may display some left-lateralisation of the normal right-lateralised temporal lobe response to emotional prosody. Declaration of interest R.M. received a studentship from Neuraxis,, and funding from the Neuroscience and Psychiatry Unit, University of Manchester.

Item Type:Article
Divisions:Life Sciences > School of Psychology and Clinical Language Sciences
ID Code:13922

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation