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Design considerations in the sequential analysis of matched case–control data

Baksh, M. F. ORCID:, Todd, S. ORCID:, Whitehead, J. and Lucini, M. M. (2005) Design considerations in the sequential analysis of matched case–control data. Statistics in Medicine, 24 (6). pp. 853-867. ISSN 0277-6715

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To link to this item DOI: 10.1002/sim.1968


A role for sequential test procedures is emerging in genetic and epidemiological studies using banked biological resources. This stems from the methodology's potential for improved use of information relative to comparable fixed sample designs. Studies in which cost, time and ethics feature prominently are particularly suited to a sequential approach. In this paper sequential procedures for matched case–control studies with binary data will be investigated and assessed. Design issues such as sample size evaluation and error rates are identified and addressed. The methodology is illustrated and evaluated using both real and simulated data sets.

Item Type:Article
Divisions:Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:18882
Uncontrolled Keywords:case-control study , efficient score , sample size , sequential methods , triangular test

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