Accessibility navigation

Understanding the effects of anesthetic agents on the EEG through neural field theory

Foster, B. L., Bojak, I. ORCID: and Liley, D. T. J. (2011) Understanding the effects of anesthetic agents on the EEG through neural field theory. In: 33rd Annual International Conference of the IEEE EMBS, 30 Aug - 03 Sep 2011, Boston, Massachusetts, pp. 4709-4712.

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Official URL:


Anesthetic and analgesic agents act through a diverse range of pharmacological mechanisms. Existing empirical data clearly shows that such "microscopic" pharmacological diversity is reflected in their "macroscopic" effects on the human electroencephalogram (EEG). Based on a detailed mesoscopic neural field model we theoretically posit that anesthetic induced EEG activity is due to selective parametric changes in synaptic efficacy and dynamics. Specifically, on the basis of physiologically constrained modeling, it is speculated that the selective modification of inhibitory or excitatory synaptic activity may differentially effect the EEG spectrum. Such results emphasize the importance of neural field theories of brain electrical activity for elucidating the principles whereby pharmacological agents effect the EEG. Such insights will contribute to improved methods for monitoring depth of anesthesia using the EEG.

Item Type:Conference or Workshop Item (Paper)
Divisions:Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN)
ID Code:32525

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation