Seizure frequency in pilocarpine-treated rats is independent of circadian rhythmBajorat, R., Wilde, M., Sellmann, T., Kirschstein, T. and Köhling, R. (2011) Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. Epilepsia, 52 (9). e118-e122. ISSN 0013-9580 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1111/j.1528-1167.2011.03200.x Abstract/SummaryPilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm.
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