Accessibility navigation

The effect of intake level on whole body kinetics and hepatic removal of somatotropin in growing beef steers

Lapierre, H., Farmer, C., Reynolds, C. K., Bernier, J. F., Lobley, G. E. and Dubreuil, P. (2000) The effect of intake level on whole body kinetics and hepatic removal of somatotropin in growing beef steers. Domestic Animal Endocrinology, 18 (2). pp. 217-227. ISSN 0739-7240

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/S0739-7240(99)00080-6


The effect of level of intake of a high concentrate diet (0.6, 1.0 and 1.6 3 maintenance requirements, M) on whole body somatotropin (St) kinetics was evaluated in six growing,multicatheterized beef steers (398 6 27 kg), using a double 3 3 3 Latin Square design with 21 d-periods. Simultaneously to St kinetics, net hepatic removal of St was measured in 4 of the 6 steers. On the last day of each period, concentrations and net fluxes of St were determined, first in basal conditions for 5 hr, and then, during a primed (0.5 mg of St) infusion of bovine St (1.5mg/hr) administered for 3 hr. The following results are LSM 6 SEM for 0.6, 1.0, and 1.6 3 M, respectively. Increasing feed intake linearly decreased (P , 0.01) basal St concentrations (5.6, 4.6,3.1 6 0.62 ng/ml), mainly through a linear increment (P , 0.01) in the metabolic clearance rate (32.7, 37.1, 43.4 6 2.60 l/hr), although secretion rate also tended to decrease (P 5 0.09; 189, 185,135 6 27.2 mg/hr). During the infusion period, net liver removal of immunoreactive ST averaged 60% of the total inflow of St. This confirms the liver is capable of removing large amounts of St, suggesting it has an important role in metabolic clearance of the hormone. Net liver removal of St, however, was not affected by intake. There was a strong correlation between the metabolic clearance rate of St with either whole body protein synthesis (r 5 0.75, P , 0.01) or protein retention (r 5 0.68, P , 0.01). Together these results indicate the importance of postsecretory metabolism of St in determining both arterial plasma concentrations of St and whole body protein anabolism.

Item Type:Article
Divisions:Life Sciences > School of Agriculture, Policy and Development > Department of Animal Sciences > Animal, Dairy and Food Chain Sciences (ADFCS)- DO NOT USE
ID Code:87105

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation