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Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria

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Castelletto, V., Edwards-Gayle, C. J. C., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Barrett, G. ORCID: https://orcid.org/0000-0003-1509-0179, Seitsonen, J., Ruokolainen, J., de Mello, L. R. and da Silva, E. R. (2020) Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria. Chemical Communications, 56. pp. 615-618. ISSN 1364-548X

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To link to this item DOI: 10.1039/c9cc07257h

Abstract/Summary

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(30-50)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:88113
Uncontrolled Keywords:Materials Chemistry, Electronic, Optical and Magnetic Materials, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Ceramics and Composites, Catalysis
Publisher:Royal Society of Chemistry (RSC)
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