WATERS SELECT SERIES MRT MALDI spot analysis for Zooarchaeology by Mass Spectrometry (ZooMS) of collagenous material

Tait, F., Michael, N. and Ruebens, K. ORCID: https://orcid.org/0000-0002-5621-5786, (2026) WATERS SELECT SERIES MRT MALDI spot analysis for Zooarchaeology by Mass Spectrometry (ZooMS) of collagenous material. protocols.io doi: 10.17504/protocols.io.n2bvjkwbngk5/v1

Abstract/Summary

This protocol gives guidance on how to set up and run a Waters™ Select Series Multi-Reflecting Time-of-Flight (MRT) with a MALDI source attachment for the purposes of Zooarchaeology by Mass Spectrometry (ZooMS) of collagenous material. ZooMS allows for taxonomic identifications to be made based on peptide mass fingerprinting of collagen type 1. The Waters MRT is an ultra-high resolution imaging instrument with MALDI spot analysis capabilities, allowing for high precision ZooMS to be carried out. This instrument has the potential to achieve sub-ppm mass accuracy, therefore, results can give peptide peaks accurate to at least one decimal place allowing for contaminants and non-diagnostic peptide markers to be distinguished.

Item Type	Web Resource
URI	https://centaur.reading.ac.uk/id/eprint/130648
Identification Number/DOI	10.17504/protocols.io.n2bvjkwbngk5/v1
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Science > School of Archaeology, Geography and Environmental Science > Department of Archaeology
Publisher	protocols.io
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