A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Baumann, M., Baxendale, I.R., Ley, S.V., Nikbin, N., Smith, C. ORCID: https://orcid.org/0000-0002-5911-5836 and Tierney, J.P. (2008) A modular flow reactor for performing Curtius rearrangements as a continuous flow process. Organic and Biomolecular Chemistry, 6. pp. 1577-1586. ISSN 1477-0520 doi: 10.1039/b801631n

Abstract/Summary

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.