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Osmotic pressure and aggregate shape in BSA/poly (ethylene glycol)-lipid/Dextran solutions

Castelletto, V., Hamley, I. W., Clifton, L. A. and Green, R. J. (2008) Osmotic pressure and aggregate shape in BSA/poly (ethylene glycol)-lipid/Dextran solutions. Biophysical Chemistry, 134 (1-2). pp. 34-38. ISSN 0301-4622

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To link to this item DOI: 10.1016/j.bpc.2008.01.004

Abstract/Summary

In this work we study the colloidal osmotic pressure (COP) and aggregate shape in phosphate saline buffer solutions (PH 7.4) containing bovine serum albumin (BSA), poly(ethylene glycol) lipid (PEG(2000)-PE) and Dextran (Dx). Dx was added to the BSA/PEG(2000)-PE system in order to increase the COP of the solution to levels comparable to the COP of healthy adults, with the aim of using the solution as a blood COP regulator. Dynamic light scattering and small angle X-ray scattering results shown the formation of BSA/PEG(2000)-PE/Dx aggregates in the solution. Osmometry results shown that the addition of Dx to the BSA/PE2000-PE system could successfully increase the COP, through the formation of BSA/PEG(2000)-PE/Dx aggregates. The BSA/PEG(2000)-PE/Dx solutions attained COP= 15 mm Hg, representing 60% of COP measured for healthy adults. (c) 2008 Elsevier B.V. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:11096
Uncontrolled Keywords:polyethylene(glycol)-lipid conjugate, Dextran, bovine serum albumin, light scattering, small angle X-ray scattering, osmometry, BOVINE SERUM-ALBUMIN, GLYCOL) LIPID CONJUGATE, POLY(ETHYLENE GLYCOL), COMPLEX-FORMATION, DIFFUSION, DEXTRAN, WATER

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