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Carbohydrate-based therapeutics

Osborn, H.M.I., Evans, P.G., Gemmell, N. and Osborne, S.D. (2004) Carbohydrate-based therapeutics. Journal of Pharmacy and Pharmacology, 56 (6). pp. 691-702. ISSN 0022-3573

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To link to this item DOI: 10.1211/0022357023619

Abstract/Summary

In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11540
Uncontrolled Keywords:PHASE OLIGOSACCHARIDE SYNTHESIS, GLYCOSIDASE INHIBITORS, CAPSULAR, POLYSACCHARIDE, ADVANCED MALIGNANCIES, CLINICAL-APPLICATIONS, ANTIINFECTIVE AGENTS, TUMOR-METASTASIS, ANTICANCER DRUGS, CANCER, VACCINES, CELLS

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