Article

Mitry, M. M. A., Greco, F. and Osborn, H. M. I. (2023) In vivo applications of bioorthogonal reactions- chemistry and targeting mechanisms. Chemistry - A European Journal. ISSN 0947-6539 (In Press)

Khater, M., Brazier, J., Greco, F. and Osborn, H. (2022) Anticancer evaluation of new organometallic ruthenium(II) flavone complexes. Medicinal Chemistry. ISSN 2632-8682 doi: https://doi.org/10.1039/D2MD00304J

Trinh, D. N., Radlinskaite, M., Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Osborn, H. M. I., Meleady, P., Spencer, D. I. R. and Monopoli, M. P. (2022) Biomolecular corona stability in association with plasma cholesterol level. Nanomaterials, 12 (15). 2661. ISSN 2079-4991 doi: https://doi.org/10.3390/nano12152661

Khater, M., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Boateng, S. Y., Greco, F. and Osborn, H. M. I. (2022) Halogenated flavonoid derivatives display antiangiogenic activity. Molecules, 27 (15). 4757. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules27154757

Cheeseman, J., Badia, C., Thomson, R. I., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Gardner, R. A., Spencer, D. I. R. and Osborn, H. M. I. (2022) Quantitative standards of 4-O acetyl and 9-O acetyl N-acetyl neuraminic acid for the analysis of plasma and serum. ChemBioChem, 23 (5). e202100662. ISSN 1439-7633 doi: https://doi.org/10.1002/cbic.202100662

Hutchins, M., Bovill, R. A., Stephens, P. J., Brazier, J. A. and Osborn, H. M. I. (2022) Glycosides of nadifloxacin—synthesis and antibacterial activities against methicillin-resistant Staphylococcus aureus. Molecules, 27 (5). 1504. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules27051504

Albadawi, D. A. I., Ravishankar, D., Vallance, T. M., Patel, K., Osborn, H. M. I. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2022) Impacts of commonly used edible plants on the modulation of platelet function. International Journal of Molecular Sciences, 23 (2). 605. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms23020605

Dodd, A., Natfji, A. A. ORCID: https://orcid.org/0000-0002-6168-4632, Evangelinos, A., Grigoletto, A., Pasut, G., Beards, F., Renshall, L., Osborn, H. M. I., Greco, F. and Harris, L. K. (2022) Conjugation to PEG as a strategy to limit the uptake of drugs by the placenta: potential applications for drug administration in pregnancy. Molecular Pharmaceutics, 19 (1). pp. 345-353. ISSN 1543-8392 doi: https://doi.org/10.1021/acs.molpharmaceut.1c00498

Donmez, S. I., Needs, S. H., Osborn, H. M. I., Reis, N. M. and Edwards, A. D. ORCID: https://orcid.org/0000-0003-2369-989X (2022) Label-free 1D microfluidic dipstick counting of microbial colonies and bacteriophage plaques. Lab on a Chip, 22 (15). pp. 2820-2831. ISSN 1473-0197 doi: https://doi.org/10.1039/d2lc00280a

Dawood, D. H., Srour, A. M., Saleh, D. O., Huff, K. J., Greco, F. and Osborn, H. M. I. (2021) New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents. RSC Advances, 11. pp. 29441-29452. ISSN 2046-2069 doi: https://doi.org/10.1039/D1RA04758B

Needs, S., Osborn, H. and Edwards, A. ORCID: https://orcid.org/0000-0003-2369-989X (2021) Counting bacteria in microfluidic devices: smartphone compatible ‘dip-and-test’ viable cell quantitation using resazurin amplified detection in microliter capillary arrays. Journal of Microbiological Methods, 187. 106199. ISSN 0167-7012 doi: https://doi.org/10.1016/j.mimet.2021.106199

Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Stafford, G., Gardner, R., Spencer, D. and Osborn, H. (2021) Sialic acid as a potential biomarker for cardiovascular disease, diabetes and cancer. Biomarkers in Medicine, 15 (11). pp. 911-928. ISSN 1752-0363 doi: https://doi.org/10.2217/bmm-2020-0776

Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Spencer, D. I.R. and Osborn, H. (2021) Assays for the identification and quantification of sialic acids: challenges, opportunities and future perspectives. Bioorganic & Medicinal Chemistry, 30. 115882. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2020.115882

Dönmez, S. İ., Needs, S. H. ORCID: https://orcid.org/0000-0003-3407-9637, Osborn, H. M. I. and Edwards, A. D. ORCID: https://orcid.org/0000-0003-2369-989X (2020) Label-free smartphone quantitation of bacteria by darkfield imaging of light scattering in fluoropolymer micro capillary film allows portable detection of bacteriophage lysis. Sensors and Actuators B: Chemical, 323. p. 128645. ISSN 0925-4005 doi: https://doi.org/10.1016/j.snb.2020.128645

Khater, M., Greco, F. and Osborn, H. M. I. (2020) Antiangiogenic activity of flavonoids: a systematic review and meta-analysis. Molecules, 25 (20). 4712. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules25204712

Needs, S., Donmez, S. I., Bull, S., McQuaid, C., Osborn, H. M. I. and Edwards, A. ORCID: https://orcid.org/0000-0003-2369-989X (2020) Challenges in microfluidic and point-of-care phenotypic antimicrobial resistance tests. Frontiers in Mechanical Engineering, 6. ISSN 2297-3079 doi: https://doi.org/10.3389/fmech.2020.00073

Natfji, A. A., Nikitin, D. O., Semina, I. I., Moustafine, R. I., Khutoryanskiy, V. V., Lin, H., Stephens, G. J., Watson, K. A., Osborn, H. M. I. and Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release, 322. pp. 227-235. ISSN 0168-3659 doi: https://doi.org/10.1016/j.jconrel.2020.02.037

Khater, M., Ravishankar, D., Greco, F. and Osborn, H. (2019) Metal complexes of flavonoids: their synthesis, characterization, and enhanced anti-oxidant and anti-cancer activities. Future Medicinal Chemistry, 11 (21). ISSN 1756-8927 doi: https://doi.org/10.4155/fmc-2019-0237

Vallance, T. M., Ravishankar, D., Albadawi, D. A. I., Osborn, H. M. I. and Vaiyapuri, S. (2019) Synthetic flavonoids as novel modulators of platelet function and thrombosis. International Journal of Molecular Sciences, 20 (12). e3106. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms20123106

Howse, G. L., Bovill, R. A., Stephens, P. J. and Osborn, H. M. I. (2019) Synthesis and antibacterial profiles of targeted triclosan derivatives. European Journal of Medicinal Chemistry, 162. pp. 51-58. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2018.10.053

Ravishankar, D., Salamah, M., Akimbaev, A., Williams, H. F., Albadawi, D. A. I., Vaiyapuri, R., Greco, F., Osborn, H. M. I. and Vaiyapuri, S. (2018) Impact of specific functional groups in flavonoids on the modulation of platelet activation. Scientific Reports, 8. 9528. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-018-27809-z

Brown, G. D., Bauer, J., Osborn, H. M. I. and Kuemmerle, R. (2018) A solution NMR approach to determine the chemical structures of carbohydrates using the hydroxyl groups as starting points. ACS Omega, 3 (12). pp. 17957-17975. ISSN 2470-1343 doi: https://doi.org/10.1021/acsomega.8b02136

Natfji, A. A., Ravishankar, D., Osborn, H. M. I. and Greco, F. (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. Journal of Pharmaceutical Sciences, 106 (11). pp. 3179-3187. ISSN 0022-3549 doi: https://doi.org/10.1016/j.xphs.2017.06.019

Natfji, A. A., Osborn, H. M. I. and Greco, F. (2017) Feasibility of polymer-drug conjugates for non-cancer applications. Current Opinion in Colloid & Interface Science, 31. pp. 51-66. ISSN 1359-0294 doi: https://doi.org/10.1016/j.cocis.2017.07.004

Thomson, R. I., Gardner, R. A., Strohfeldt, K., Fernandes, D. L., Stafford, G. P., Spencer, D. I. R. and Osborn, H. M. I. (2017) Analysis of three epoetin alpha products by LC and LC-MS indicates differences in glycosylation critical quality attributes, including sialic acid content. Analytical Chemistry, 89 (12). pp. 6455-6462. ISSN 0003-2700 doi: https://doi.org/10.1021/acs.analchem.7b00353

Ravishankar, D., Salamah, M., Attina, A., Pothi, R., Vallance, T. M., Javed, M., Williams, H. F., Alzahrani, E. M. S., Kabova, E., Vaiyapuri, R., Shankland, K., Gibbins, J., Strohfeldt, K., Greco, F., Osborn, H. M. I. and Vaiyapuri, S. (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Scientific Reports, 7. 5738. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-017-05936-3

Heath, F., Newman, A., Clementi, C., Pasut, G., Lin, H., Stephens, G. J., Whalley, B. J., Osborn, H. M. I. and Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry, 7 (47). pp. 7204-7210. ISSN 1759-9954 doi: https://doi.org/10.1039/c6py01418f

Ravishankar, D., Corona, G., Hogan, S. M., Spencer, J. P. E., Greco, F. and Osborn, H. M. I. (2016) Thioflavones as novel neuroprotective agents. Bioorganic & Medicinal Chemistry, 24 (21). pp. 5513-5520. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2016.09.006

Bovill, R., Evans, P. G., Howse, G. L. and Osborn, H. M. I. (2016) Synthesis and biological analysis of novel glycoside derivatives of L-AEP, as targeted antibacterial agents. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3774-3779. ISSN 0960-894X doi: https://doi.org/10.1016/j.bmcl.2016.05.052

Ravishankar, D., Watson, K. A., Greco, F. and Osborn, H. M. I. (2016) Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances, 6 (69). pp. 64544-64556. ISSN 2046-2069 doi: https://doi.org/10.1039/C6RA11041J

Parshotam, J. P., Brazier, J. A., Bovill, R. and Osborn, H. M. I. (2016) An efficient and rapid microwave-assisted synthesis of 1-acetyl-1H-indol-3-YL acetates. Current Microwave Chemistry, 3 (3). pp. 247-257. ISSN 2213-3364 doi: https://doi.org/10.2174/2213335603666160108001556

Bauer, J. and Osborn, H. M. I. (2015) Sialic acids in biological and therapeutic processes: opportunities and challenges. Future Medicinal Chemistry, 7 (16). pp. 2285-2299. ISSN 1756-8927 doi: https://doi.org/10.4155/fmc.15.135

Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056

Rajora, A. K., Ravishankar, D., Osborn, H. M.I. and Greco, F. (2014) Impact of the enhanced permeability and retention (EPR) effect and cathepsins levels on the activity of polymer-drug conjugates. Polymers, 6 (8). pp. 2186-2220. ISSN 2073-4360 doi: https://doi.org/10.3390/polym6082186

Ravishankar, D., Rajora, A., Greco, F. and Osborn, H. (2013) Flavonoids as prospective compounds for anti-cancer therapy. International Journal of Biochemistry and Cell Biology, 45 (12). pp. 2821-2831. ISSN 1878-5875 doi: https://doi.org/10.1016/j.biocel.2013.10.004

Jarvis, A. N., McClaren, A. B., Osborn, H. M. I. and Sweeney, J. (2013) Preparation and ring-opening reactions of N-diphenylphosphinyl vinyl aziridines. Beilstein Journal of Organic Chemistry, 9. pp. 852-859. ISSN 1860-5397 doi: https://doi.org/10.3762/bjoc.9.98

Burland, P. A., Osborn, H. M. I. and Turkson, A. (2011) Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. Bioorganic & Medicinal Chemistry, 19 (18). pp. 5679-5692. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2011.07.019

Fante, C., Eldar-Boock, A., Satchi-Fainaro, R., Osborn, H. M. I. and Greco, F. (2011) Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent. Journal of Medicinal Chemistry, 54 (14). pp. 5255-5259. ISSN 0022-2623 doi: https://doi.org/10.1021/jm200382r

Benning, R. K., Osborn, H. M. I. and Turkson, A. (2011) Regioselective Beckmann rearrangements of furanoside and pyranoside-derived oximes. Tetrahedron: Asymmetry, 22 (1). pp. 109-116. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2010.11.031

Burland, P. A., Coisson, D. and Osborn, H. M. I. (2010) Rapid synthesis of carbohydrate derivatives, including mimetics of c-linked disaccharides and c-Linked aza disaccharides, using the Hetero-Diels−Alder Reaction. Journal of Organic Chemistry, 75 (21). pp. 7210-7218. ISSN 0022-3263 doi: https://doi.org/10.1021/jo101219w

Carlescu, I., Osborn, H. M.I., Desbrieres, J., Scutaru, D. and Popa, M. (2010) Synthesis of poly(aspartimide)-based bio-glycoconjugates. Carbohydrate Research, 345 (1). pp. 33-40. ISSN 0008-6215 doi: https://doi.org/10.1016/j.carres.2009.08.034

Osborn, H. M. I. and Turkson, A. (2009) Synthesis and NMR spectroscopic analysis of 3-nitro-pyranoside, 3-nitro-septanoside and 4-nitro-septanoside derivatives by condensation of the anion of nitromethane with glycoside. Tetrahedron Asymmetry, 20 (18). pp. 2162-2166. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2009.08.004

Jawaid, S., Khan, T. H., Osborn, H. M. I. and Williams, N. O. A. (2009) Tyrosinase activated melanoma prodrugs. Anti-cancer agents in medicinal chemistry, 9 (7). pp. 717-727. ISSN 1871-5206

Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I., Williams, N. A.O. and Yaqoob, P. (2008) Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma. Journal of Medicinal Chemistry, 51 (20). pp. 6604-6608. ISSN 0022-2623 doi: https://doi.org/10.1021/jm8007745

Ellis, D., Norman, S. E. and Osborn, H. M. I. (2008) Synthesis of S-linked carbohydrate analogues via a Ferrier reaction. Tetrahedron, 64 (12). pp. 2832-2854. ISSN 0040-4020 doi: https://doi.org/10.1016/j.tet.2008.01.042

Owen, R.E., Yamada, E., Thompson, C.I., Phillipson, L.J., Thompson, C., Taylor, E., Zambon, M., Osborn, H.M.I., Barclay, W.S. and Borrow, P. (2007) Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells. Journal of Virology, 81 (20). pp. 11170-11178. ISSN 0022-538X doi: https://doi.org/10.1128/jvi.01217-07

Jawaid, S., Osborn, H.M.I. and Williams, N.A.O. (2007) Fighting skin cancer with prodrugs. Education in Chemistry, 44 (3). pp. 77-81. ISSN 0013-1350

Liu, Y., Feizi, T., Carnpanero-Rhodes, M.A., Childs, R.A., Zhang, Y.N., Muiioy, B., Evans, P.G., Osborn, H.M.I., Otto, D., Crocker, P.R. and Chai, W.C. (2007) Neoglycolipid probes prepared via oxime ligation for microarray analysis of oligosaccharide-protein interactions. Chemistry & Biology, 14 (7). pp. 847-859. ISSN 1074-5521 doi: https://doi.org/10.1016/j.chembiol.2007.06.009

Barclay, W.S., Jones, I.M., Osborn, H.M.I., Phillipson, L., Ren, J.Y., Talevera, G.A. and Thompson, C.I. (2007) Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands. Bioorganic & Medicinal Chemistry, 15 (12). pp. 4038-4047. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2007.03.085

Chai, W., Piskarev, V.E., Mulloy, B., Liu, Y., Evans, P.G., Osborn, H.M.I. and Lawson, A.M. (2006) Analysis of chain and blood group type and branching pattern of sialylated oligosaccharides by negative ion electrospray tandem mass spectrometry. Analytical Chemistry, 78 (5). pp. 1581-1592. ISSN 0003-2700 doi: https://doi.org/10.1021/ac051606e

Brome, V.A., Harwood, L.M. and Osborn, H.M.I. (2006) Preparation of enantiopure long chain threo-2-amino-3-hydroxyesters via chiral morpholinone-derived azomethine ylids. Canadian Journal of Chemistry-Revue Canadienne De Chimie, 84 (10). pp. 1448-1455. ISSN 0008-4042 doi: https://doi.org/10.1139/v06-121

Osborn, H.M.I. (2005) Development of new methodologies for entry to targets of therapeutic interest. Synlett (17). pp. 2571-2586. ISSN 0936-5214 doi: https://doi.org/10.1055/s-2005-917076

Knaggs, S., Malkin, H., Osborn, H.M.I., Williams, N.A.O. and Yaqoob, P. (2005) New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). Organic & Biomolecular Chemistry, 3 (21). pp. 4002-4010. ISSN 1477-0520 doi: https://doi.org/10.1039/b506404j

Osborn, H.M.I., Meo, P. and Nijara, R.K. (2005) A new entry to 4,6-O-benzylidene glucal from phenyl 1-seleno-alpha-D-mannopyranoside. Tetrahedron-Asymmetry, 16 (11). pp. 1935-1937. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2005.05.004

Osborn, H.M.I. and Coisson, D. (2004) Application of the asymmetric hetero Diels-Alder reaction for synthesising carbohydrate derivatives and glycosidase inhibitors. Mini-Reviews in Organic Chemistry, 1 (1). pp. 41-54. ISSN 1570-193X doi: https://doi.org/10.2174/1570193043488953

Osborn, H.M.I., Evans, P.G., Gemmell, N. and Osborne, S.D. (2004) Carbohydrate-based therapeutics. Journal of Pharmacy and Pharmacology, 56 (6). pp. 691-702. ISSN 0022-3573 doi: https://doi.org/10.1211/0022357023619

Osborn, H.M.I. and Williams, N.A.O. (2004) Development of tyrosinase labile protecting groups for amines. Organic Letters, 6 (18). pp. 3111-3113. ISSN 1523-7060 doi: https://doi.org/10.1021/ol040042i

Clark, S.M. and Osborn, H.M.I. (2004) Synthetic entry to functionalised morpholines and [1,4]-oxazepanes via reductive amination reactions of carbohydrate derived dialdehydes. Tetrahedron-Asymmetry, 15 (22). pp. 3643-3652. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2004.10.002

Hayes, W., Osborn, H.M.I., Osborne, S.D., Rastall, R.A. and Romagnoli, B. (2003) One-pot synthesis of multivalent arrays of mannose mono- and disaccharides. Tetrahedron, 59 (40). pp. 7983-7996. ISSN 0040-4020 doi: https://doi.org/10.1016/j.tet.2003.08.011

Gemmell, N., Meo, P. and Osborn, H.M.I. (2003) Stereoselective entry to beta-linked C-disaccharides using a carbon-Ferrier reaction. Organic Letters, 5 (10). pp. 1649-1652. ISSN 1523-7060 doi: https://doi.org/10.1021/ol030023t

Jordan, A.M., Osborn, H.M.I., Stafford, P.M., Tzortzis, G. and Rastall, R.A. (2003) Synthesis of unsaturated aminopyranosides as possible transition state mimics for glycosidases. Journal of Carbohydrate Chemistry, 22 (7-8). pp. 705-717. ISSN 0732-8303 doi: https://doi.org/10.1081/car-120026469

Book or Report Section

Osborn, H.M.I. and Turkson, A. (2009) Sugars as pharmaceuticals. In: Gabius, H.-J. (ed.) The sugar code: fundamentals of glycosciences. Wiley-VCH, Weinheim, pp. 469-485. ISBN 9783527320899

Osborn, H.M.I., Evans, P.G. and Bezouska, K. (2008) Biomedicine of monosaccharides. In: Fraser-Reid, B.O., Tatsuta, K., Thiem, J., Coté, G.L., Flitsch, S., Ito, Y., Kondo, H., Nishimura, S.-i. and Yu, B. (eds.) Glycoscience: chemistry and chemical biology. Springer , Berlin, pp. 2399-2444. ISBN 9783540304296

Book

Osborn, H.M.I. (2003) Carbohydrates. Best synthetic methods. Academic Press, Oxford. ISBN 9780123120854