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In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longum biovar infantis

Vulevic, J. and Gibson, G.R. (2008) In vitro effects of phosphatidylcholine and transgalactooligosaccharides on the production of 1,2-sn-diacylglycerol by Bifidobacterium longum biovar infantis. Journal of Applied Microbiology , 105 (5). pp. 1678-1685. ISSN 1364-5072

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To link to this article DOI: 10.1111/j.1365-2672.2008.03886.x

Abstract/Summary

Aims: To investigate the production of the tumour promoter 1,2-sn-diacylglycerol (DAG) by a human gut isolate of Bifidobacterium longum biovar infantis. Methods and Results: Bifidobacterium longum biovar infantis was grown in vitro using anaerobic static batch cultures in the presence of phosphatidylcholine (PC) and trans-galactooligosaccharides (TOS). Production of DAG was found to be dependent upon the presence of PC, while TOS had a reducing effect. Considerable differences in morphology, growth and metabolic end products from the micro-organism were observed under the different culture conditions. Conclusions: Our results have provided evidence that B. longum biovar infantis can produce DAG in vitro and that a prebiotic exerted a reducing effect upon this production. Significance and Impact of the Study: The results presented in this study demonstrate an ability of ostensibly beneficial member of the colonic environment to produce unwanted compounds under certain conditions. Therefore, it may be important that a combination of substrates and other factors are assessed when studying the behaviour of any bacterial group or species, especially when designing the dietary interventions.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:12883
Uncontrolled Keywords:bifidobacteria, diacylglycerol, fermentation, lipid metabolism, phosphatidylcholine, prebiotics, tumour promotion , PROTEIN-KINASE-C, LACTIC-ACID BACTERIA, HIGH-FAT DIETS, CHOLESTEROL ASSIMILATION, PHOSPHOLIPID COMPOSITION, DIACYLGLYCEROL, MICROBIOTA, GUT, MICROFLORA, STIMULATE

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