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Antioxidant and free radical scavenging activity of isoflavone metabolites

Rimbach, G., De Pascual-Teresa, S., Ewins, B.A., Matsugo, S., Uchida, Y., Minihane, A.M., Turner, R., VafeiAdou, K. and Weinberg, P.D. (2003) Antioxidant and free radical scavenging activity of isoflavone metabolites. Xenobiotica, 33 (9). pp. 913-925. ISSN 0049-8254

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To link to this article DOI: 10.1080/0049825031000150444

Abstract/Summary

1. Soy isoflavones have been extensively studied because of their possible health-promoting effects. Genistein and daidzein, the major isoflavone aglycones, have received most attention; however, they undergo extensive metabolism in the gut and liver, which might affect their biological properties. 2. The antioxidant activity, free radical-scavenging properties and selected cellular effects of the isoflavone metabolites equol, 8-hydroxydaidzein, O-desmethylangiolensin, and 1,3,5 trihydroxybenzene were investigated in comparison with their parent aglycones, genistein and daidzein. 3. Electron spin resonance spectroscopy indicated that 8-hydroxydaidzein was the most potent scavenger of hydroxyl and superoxide anion radicals. Isoflavone metabolites also exhibited higher antioxidant activity than parent compounds in standard antioxidant (FRAP and TEAC) assays. However, for the suppression of nitric oxide production by activated macrophages, genistein showed the highest potency, followed by equol and daidzein. 4. The metabolism of isoflavones affects their free radical scavenging and antioxidant properties, and their cellular activity, but the effects are complex.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13047
Uncontrolled Keywords:RAW 264.7 MACROPHAGES, TNF-ALPHA SECRETION, NITRIC-OXIDE, IN-VITRO, SOY, ISOFLAVONES, GENE-EXPRESSION, PHYTOESTROGENS, GENISTEIN, FLAVONOIDS, DAIDZEIN

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