Polymorphisms in the apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males
Page, N.M., Olano-Martin, E., Lanaway, C., Turner, R. and Minihane, A.M. (2006) Polymorphisms in the apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males. Genes and Nutrition, 1 (2). pp. 133-135. ISSN 1555-8932
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To link to this article DOI: 10.1007/BF02829955
Apolipoprotein L1 in plasma is associated with high- density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lys166Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.