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A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans

Kolida, S., Meyer, D. and Gibson, G.R. (2007) A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. European Journal of Clinical Nutrition, 61 (10). pp. 1189-1195. ISSN 0954-3007

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To link to this article DOI: 10.1038/sj.ejcn.1602636

Abstract/Summary

Objective: To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults. Design: A double-blind, placebo-controlled, crossover human study. Setting: Food Microbial Sciences Unit, The University of Reading, Reading, UK. Subjects: Thirty healthy volunteers, 15 men, 15 women ( age range 19-35). Interventions: Subjects consumed a chocolate drink containing placebo ( maltodextrin, 8 g/day), 5 g/day inulin and 8 g/day inulin for a 2-week treatment period. Each treatment was followed by a 1-week washout at the end of which volunteers progressed to the next treatment. Faecal samples were obtained at the start of the study ( baseline) and at the end of each treatment and washout period. Fluorescent in situ hybridization was used to monitor populations of Bifidobacterium genus, Bacteroides - Prevotella, Lactobacillus - Enterococcus and Clostridium perfringens - histolyticum subgroup. Results: Bifidobacterial levels increased significantly upon ingestion of both the low ( 9.78 +/- 0.29 log(10) cells/g faeces, P < 0.05) and the high inulin dose ( 9.79 +/- 0.38 log(10) cells/g faeces, P < 0.05) compared to placebo ( 9.64 +/- 0.23 log(10) cells/g faeces). Conclusions: Both inulin doses exhibited a bifidogenic effect but a higher volunteer percentage responded to the high dose. A dose response effect was not observed but the magnitude of increase in bifidobacteria levels depended on their initial numbers. The higher the initial concentrations the smaller was the increase upon ingestion of the active treatments. Sponsorship: Financial support for the completion of this project was provided by Sensus ( Roosendaal, The Netherlands).

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13243
Uncontrolled Keywords:inulin, FISH, prebiotic, colon, Bifidobacterium, IN-SITU HYBRIDIZATION, FECAL BIFIDOBACTERIA, OLIGONUCLEOTIDE PROBES, HUMAN VOLUNTEER, OLIGOFRUCTOSE, OLIGOSACCHARIDES, BACTERIA, NEOSUGAR

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