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The effects of alpha-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri

Bruck, W.M., Kelleher, S.L., Gibson, G.R., Graverholt, G. and Lonnerdal, B.L. (2006) The effects of alpha-lactalbumin and glycomacropeptide on the association of CaCo-2 cells by enteropathogenic Escherichia coli, Salmonella typhimurium and Shigella flexneri. Fems Microbiology Letters, 259 (1). pp. 158-162. ISSN 0378-1097

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To link to this item DOI: 10.1111/j.1574-6968.2006.00268.x

Abstract/Summary

Two milk components, alpha-lactalbumin (alpha-La) and glycomacropeptide (GMP) may inhibit intestinal infection/intoxification. (3)[H] thymidine-labeled enteropathogenic Escherichia coli (EPEC), Salmonella typhimurium (ATCC 6994) or Shigella flexneri (ATCC 9199) were introduced to CaCo-2 cultures and their association with CaCo-2 cells was assessed. Undigested, pepsin-digested and pepsin- and pancreatin-digested alpha-lactalbumin and glycomacropeptide inhibited association. Thus, milk supplemented with alpha-lactalbumin and glycomacropeptide might be effective in inhibiting associations of the pathogens EPEC, Salmonella typhimurium, and Shigella flexneri to intestinal cells.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13534
Uncontrolled Keywords:alpha-lactalbumin, glycomacropeptide, Salmonella spp, enteropathogenic, Escherichia coli, Shigella spp, milk proteins, MILK, PATHOGENS, DIARRHEA, CHILDREN

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