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The mammalian cell cycle: an overview

Harper, J.V. and Brooks, G. (2005) The mammalian cell cycle: an overview. In: Humphrey, T. and Brooks, G. (eds.) Cell cycle control: mechanisms and protocols. Methods in molecular biology, 296. Humana Press, New Jersey, pp. 113-153. ISBN 9781588291448

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To link to this article DOI: 10.1385/1-59259-857-9:113

Abstract/Summary

In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly regulated at each phase of the cell cycle by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. This review article describes the various phases of the mammalian cell cycle and focuses on the cell cycle regulatory molecules that act at each stage to ensure normal cellular progression.

Item Type:Book or Report Section
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13737
Uncontrolled Keywords:14-3-3, anaphase-promoting complex, CDC25, cyclins, cyclin-dependent kinases (Cdks), Cdk inhibitors, cytokinesis, DNA replication, E2F transcription factors, endoreduplication, MAP kinase, pocket proteins, SCF ubiquitin ligases
Publisher:Humana Press

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