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Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques

Ahmed, A., Barry, B. W., Williams, A. C. and Davis, A. F. (2004) Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques. Journal of Pharmaceutical and Biomedical Analysis, 34. pp. 945-956. ISSN 0731-7085

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To link to this article DOI: 10.1016/j.jpba.2003.11.018

Abstract/Summary

The solubility of penciclovir (C10N5O3H17) in a novel film formulation designed for the treatment of cold sores was determined using X-ray, thermal, microscopic and release rate techniques. Solubilities of 0.15–0.23, 0.44, 0.53 and 0.42% (w/w) resulted for each procedure. Linear calibration lines were achieved for experimentally and theoretically determined differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) data. Intra- and inter-batch data precision values were determined; intra values were more precise. Microscopy was additionally useful for examining crystal shape, size distribution and homogeneity of drug distribution within the film. Whereas DSC also determined melting point, XRPD identified polymorphs and release data provided relevant kinetics.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:27357
Publisher:Elsevier

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