JAMming the signals
Gibbins, J. (2012) JAMming the signals. Blood, 119 (14). pp. 3197-3198. ISSN 1528-0020
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To link to this article DOI: 10.1182/blood-2012-02-409060
In this issue of Blood, Naik and colleagues have identified a new mechanism used by platelets to inhibit the signals that drive their activation through integrin αIIbβ3,which serves to prevent inappropriate or premature thrombus formation. Comment on: JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets. [Blood. 2012]