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The negative regulation of platelet function: extending the role of the ITIM

Gibbins, J. M. (2002) The negative regulation of platelet function: extending the role of the ITIM. Trends in Cardiovascular Medicine, 12 (5). pp. 213-219. ISSN 1050-1738

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Official URL: http://www.tcmonline.org/article/S1050-1738(02)001...

Abstract/Summary

The central role of immune-receptorlike signaling mechanisms in the activation of platelets at sites of vascular injury is well established. Of equal importance to the regulatory systems that control the activation of platelets are those systems that negatively regulate platelets and thereby prevent inappropriate platelet activation and thrombosis. Recent reports have identified a new mechanism through which this may be achieved, which involves signaling via a receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM). The role of ITIMs in the control of platelet function is the subject of this review.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:29067
Uncontrolled Keywords:Haemostasis, thrombosis, platelets, ITIM
Publisher:Elsevier

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