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Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current

Dallas, M. L., Yang, Z., Boyle, J. P., Boycott, H. E., Scragg, J. L., Milligan, C. J., Elies, J., Duke, A., Thireau, J., Reboul, C., Richard, S., Bernus, O., Steele, D. S. and Peers, C. (2012) Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. American Journal of Respiratory and Critical Care Medicine, 186 (7). pp. 648-656. ISSN 1535-4970

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To link to this item DOI: 10.1164/rccm.201204-0688OC

Abstract/Summary

Our data indicate that the proarrhythmic effects of CO arise from activation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late Na(+) current. We also show that the antianginal drug ranolazine can abolish CO-induced early after-depolarizations, highlighting a novel approach to the treatment of CO-induced arrhythmias.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
No Reading authors. Back catalogue items
ID Code:30338
Uncontrolled Keywords:carbon monoxide; arrhythmia; late Na+ channel; nitric oxide; S-nitrosylation
Publisher:American Thoracic Society

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