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Immunopharmacology: utilizing antibodies as ion channel modulators

Dallas, M. L., Deuchars, S. A. and Deuchars, J. (2010) Immunopharmacology: utilizing antibodies as ion channel modulators. Expert Review of Clinical Pharmacology, 3 (3). pp. 281-289. ISSN 1751-2433

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To link to this item DOI: 10.1586/ecp.10.18

Abstract/Summary

Development of the patch clamp technique by the Nobel Prize winners Bert Sakmann and Erwin Neher led to huge advances in ion channel research. Their work laid the foundations and revolutionized electrophysiological studies of cells and ion channels. These ion channels underlie many basic cellular physiological processes and, therefore, are key therapeutic targets for pharmaceutical companies. However, current pharmacological strategies are hampered by the lack of specific ion channel blockers. Intense research and development programs are now actively employing antibodies to target ion channels in various formats. This review discusses the use of ion channel antibodies and their associated small molecules as pharmacological tools, termed immunopharmacology. In addition, we will review some recent studies looking into clinical applications of immunopharmacology and intrabodies.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
No Reading authors. Back catalogue items
ID Code:30344
Publisher:Future Drugs

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