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MALDI mass spectrometry in prostate cancer biomarker discovery

Flatley, B., Malone, P. and Cramer, R. (2014) MALDI mass spectrometry in prostate cancer biomarker discovery. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1844 (5). pp. 940-949. ISSN 1570-9639

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To link to this item DOI: 10.1016/j.bbapap.2013.06.015

Abstract/Summary

Matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry (MS) is a highly versatile and sensitive analytical technique, which is known for its soft ionisation of biomolecules such as peptides and proteins. Generally, MALDI MS analysis requires little sample preparation, and in some cases like MS profiling it can be automated through the use of robotic liquid-handling systems. For more than a decade now, MALDI MS has been extensively utilised in the search for biomarkers that could aid clinicians in diagnosis, prognosis, and treatment decision making. This review examines the various MALDI-based MS techniques like MS imaging, MS profiling and proteomics in-depth analysis where MALDI MS follows fractionation and separation methods such as gel electrophoresis, and how these have contributed to prostate cancer biomarker research. This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:36427
Uncontrolled Keywords:Prostate cancer; Biomarkers; MALDI MS; MS profiling; MS imaging
Publisher:Elsevier

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