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Genetic, structural, and molecular insights into the function of ras of complex proteins domains

Civiero, L., Dihanich, S., Lewis, P. A. and Greggio, E. (2014) Genetic, structural, and molecular insights into the function of ras of complex proteins domains. Chemistry and Biology, 21 (7). pp. 809-818. ISSN 1074-5521

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To link to this item DOI: 10.1016/j.chembiol.2014.05.010

Abstract/Summary

Ras of complex proteins (ROC) domains were identified in 2003 as GTP binding modules in large multidomain proteins from Dictyostelium discoideum. Research into the function of these domains exploded with their identification in a number of proteins linked to human disease, including leucine-rich repeat kinase 2 (LRRK2) and death-associated protein kinase 1 (DAPK1) in Parkinson’s disease and cancer, respectively. This surge in research has resulted in a growing body of data revealing the role that ROC domains play in regulating protein function and signaling pathways. In this review, recent advances in the structural informa- tion available for proteins containing ROC domains, along with insights into enzymatic function and the integration of ROC domains as molecular switches in a cellular and organismal context, are explored.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:37255
Publisher:Cell Press

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