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Nutrimetabonomics: nutritional applications of metabolic profiling

Swann, J. R. and Claus, S. P. (2014) Nutrimetabonomics: nutritional applications of metabolic profiling. Science Progress, 97 (1). pp. 41-47. ISSN 0036-8504

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To link to this item DOI: 10.3184/003685014X13898807933527

Abstract/Summary

An individual's metabolic phenotype, and ultimately health, is significantly influenced by complex interactions between their genes and the diet. Studying these associations and their downstream biochemical consequences has proven extremely challenging using traditional hypothesis-led strategies. Metabonomics, a systems biology approach, allows the global metabolic response of biological systems to stimuli to be characterised. Through the application of this approach to nutritional-based research, nutrimetabonomics, the biochemical response to dietary inputs is being investigated at greater levels of resolution. This has allowed novel insights to be gained regarding intricate diet-gene interactions and their consequences for health and disease. In this review, we present some of the latest research exploring how nutrimetabonomics can assist in the elucidation of novel biomarkers of dietary behaviour and provide new perspectives on diet-health relationships. The use of this approach to study the metabolic interplay between the gut microbiota and the host is also explored.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > NMR (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
ID Code:38450
Uncontrolled Keywords:GUT MICROBIOTA; METABOLIC PROFILING; NUTRIMETABONOMICS; NUTRITION
Publisher:Science Reviews 2000 Ltd

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