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Sample preparation: a crucial factor for the analytical performance of rationally designed MALDI matrices

Wiangnon, K. and Cramer, R. (2015) Sample preparation: a crucial factor for the analytical performance of rationally designed MALDI matrices. Analytical Chemistry, 87 (3). pp. 1485-1488. ISSN 0003-2700

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To link to this item DOI: 10.1021/ac504412p

Abstract/Summary

Evidence is presented that the performance of the rationally designed MALDI matrix 4-chloro-α-cyanocinnamic acid (ClCCA) in comparison to its well-established predecessor α-cyano-4-hydroxycinnamic acid (CHCA) is significantly dependent on the sample preparation, such as the choice of the target plate. In this context, it becomes clear that any rational designs of MALDI matrices and their successful employment have to consider a larger set of physicochemical parameters, including sample crystallization and morphology/topology, in addition to parameters of basic (solution and/or gas-phase) chemistry.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:39084
Publisher:American Chemical Society

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