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Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells

Widera, D., Hauser, S., Kaltschmidt, C. and Kaltschmidt, B. (2012) Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells. Anatomy research international, 2012. 837626. ISSN 2090-2751

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To link to this item DOI: 10.1155/2012/837626

Abstract/Summary

Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:39513
Publisher:Hidawi Press

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