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Norepinephrine ignites local hot spots of neuronal excitation: how arousal amplifies selectivity in perception and memory

Mather, M., Clewett, D., Sakaki, M. and Hearley, C. W. (2016) Norepinephrine ignites local hot spots of neuronal excitation: how arousal amplifies selectivity in perception and memory. Behavioral and Brain Sciences, 39. e200. ISSN 0140-525X

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To link to this item DOI: 10.1017/S0140525X15000667

Abstract/Summary

Arousal sometimes enhances and sometimes impairs perception and memory. In our Glutamate Amplifies Noradrenergic Effects (GANE) model, glutamate at active synapses interacts with norepinephrine released by the locus coeruleus to create local ‘hot spots’ of activity that enable the selective effects of arousal. This hot spot mechanism allows local cortical regions to self-regulate norepinephrine release based on current activation levels. In turn, hot spots bias global energetic delivery and functional network connectivity to enhance processing of high priority representations and impair processing of lower priority representations.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
ID Code:40516
Publisher:Cambridge University Press

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