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Probing the mucoadhesive interactions between porcine gastric mucin and some water-soluble polymers

Albarkah, Y. R., Green, R. J. and Khutoryanskiy, V. V. (2015) Probing the mucoadhesive interactions between porcine gastric mucin and some water-soluble polymers. Macromolecular Bioscience, 15 (11). pp. 1546-1553. ISSN 1616-5187

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To link to this item DOI: 10.1002/mabi.201500158

Abstract/Summary

This study investigates the structural features of porcine gastric mucin (PGM) in aqueous dispersions and its interactions with water-soluble polymers (poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide), and poly(ethylene glycol)) using isothermal titration calorimetry, turbidimetric titration, dynamic light scattering, and transmission electron microscopy. It is established that PAA (450 kDa) and PMAA (100 kDa) exhibit strong specific interactions with PGM causing further aggregation of its particles, while PAA (2 kDa), poly(ethylene oxide) (1 000 kDa), and poly(ethylene glycol) (10 kDa) do not show any detectable effects on mucin. Sonication of mucin dispersions prior to their mixing with PAA (450 kDa) and PMAA (100 kDa) leads to more pronounced intensity of interactions.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:40727
Publisher:Wiley

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