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Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics

Timms, J. F., Hale, O. J. and Cramer, R. (2016) Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics. Expert Review of Proteomics, 13 (6). pp. 593-607. ISSN 1478-9450

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To link to this item DOI: 10.1080/14789450.2016.1182431

Abstract/Summary

Introduction: The last 20 years have seen significant improvements in the analytical capabilities of biological mass spectrometry. Studies using advanced mass spectrometry (MS) have resulted in new insights into cell biology and the aetiology of diseases as well as its use in clinical applications. Areas Covered: This review will discuss recent developments in MS-based technologies and their cancer-related applications with a focus on proteomics. It will also discuss the issues around translating the research findings to the clinic and provide an outline of where the field is moving. Expert Opinion: Proteomics has been problematic to adapt for the clinical setting. However, MS-based techniques continue to demonstrate potential in novel clinical uses beyond classical cancer proteomics.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:66156
Uncontrolled Keywords:Mass spectrometry, cancer research, cancer proteomics, clinical diagnostics, clinical mass spectrometry, mass spectrometry imaging, REIMS, MALDI, biotyping, pharmacokinetics
Publisher:Taylor & Francis

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